Job opportunity

Current Vacancies

  • 3 post-docoral positions
  • Technician
  • 3 positions in epic-xs

Publication date:

Jan 27th 2022

Three post-doctoral positions (1.0 FTE)

In the Hecklab at Utrecht University a variety of exciting research projects seek self-motivated researchers to tackle them. The research emphasis is on the development of advanced mass spectrometry based methods for proteomics and structural biology. The group houses and excellent infrastructure, including a dozen state-of-the-art mass spectrometers, advanced separation technologies, bioinformatics and laboratories for cell culture, biochemistry and molecular biology. The research group is quite vibrant with over 15 nationalities being present. Utrecht is a great place to be.

Short description of available Positions

Postdocs (minimum of 2 years)

 

  1. Analytical Mass Spectrometry with experience in instrumentation/engineering
    Optimization of high-resolution native mass spectrometry, with the aim to generate higher sensitivity and resolving power and secondly, optimize workflows for data-integration (e.g. middle-down, top-down and native) for both serum proteins and pharmaceutical proteins. Expertise with mass analyzers and laser equipment is beneficial, as well as programming.

 

  1. High-resolution charge detection mass spectrometry with applications to pharmaceutical glycoproteins, mRNA and glycoconjugates
    Further optimization of charge detection mass spectrometry with the aim to expand its usage to non-proteaceous samples, in collaboration with a global biopharmaceutical company. Evaluation of UHMR High Resolution mass spectrometry with and without charge reduction and/or charge detection mass spectrometry to complex biotherapeutics, including glycosylated proteins, mRNA and glycoconjugates. 

 

  1. Monitoring immunoglobulin repertoires in body fluids
    Further development of top-down and bottom-up proteomics technologies to characterize the IgG and IgA repertoires in serum (and other body fluids) and monitor changes in abundance, interactions, and modifications longitudinally under physiological changes. Translational aspects include analysing serum samples of patients during disease development, such as virus or bacterial infections.

 

Information

  • Position:  Post-doctoral
  • Location: Utrecht University, Utrecht, Netherlands
  • Duration: 2 years (minimum)
  • Startdate: After consultation; as soon as possible
  • Background: Mass Spectrometry, (LC-MS/MS, proteomics, native mass spectrometry is considered a plus). Biochemical methodology, biochemistry
  • Apply with motivation letter, cv and 2 references
  • Deadline for application: march 15th 2022
  • For information or application: c.c.heuzer@nulluu.nl,  Corine Heuzer. 
  • every applicant will be considered from the moment that they apply

 

Publication date:

27 jan 2022

Technician Analytical Biomolecular Mass Spectrometry (1.0 FTE)

Function

As our new Technician you will assist in the general research projects, with emphasis on proteomics workflows consisting of sample preparation, chromatographic separation, and MS-based characterization and quantitation of peptides and proteins. In addition, you will support the group by measuring intact native proteins with specialized mass spectrometry instrumentation, like HDX, Orbi-traps and TOF’s. Part of your time will be spent managing and running a fee for service to biopharmaceutical companies, by solving ‘research’ questions using native mass spectrometry. You will support the proteomics research by maintaining analytical equipment such as the HPLC (RP, SEC, IEX, HpH), centrifuges, etc. Furthermore, you will maintain the stock of consumables and materials and where needed assist in testing and improving the used methodology and instrumental setup.

Profile

We are looking for a hands-on, flexible, self-motivated colleague who is also a team player, open minded and creative and last but not least: you are driven by knowledge and results through your passion and enthusiasm!

You also have:

  • a Bachelor’s or Master’s in science education in analytical chemistry, biochemistry or a related field;
  • good interpersonal skills and a proven ability to communicate effectively and work well with your colleagues;
  • self-initiative and you are eager to learn and to improve current workflows;
  • the ability to follow instructions and take direction;
  • skills in using standard productivity software;
  • a demonstrated knowledge and experience in mass spectrometric techniques like LC-MS/MS, proteomics and native mass spectrometry (considered a plus);
  • experience with analytical and biochemical methods such as liquid chromatography based fractionation of peptides and proteins (considered a plus);
  • good verbal and written communication skills in Dutch and/or English and you can maintain/build good customer relations.

Offer

  • A position for 1 year with a possible extension to 3-4 years or longer;
  • A full-time gross salary ranging from €2,329 to €3,144 starting in scale 7;
  • Benefits including 8% holiday bonus and 8.3% end-of-year bonus;
  • A pension scheme, partially paid parental leave, and flexible employment conditions externe linkbased on the Collective Labour Agreement Dutch Universities (cao).

In addition to the employment conditions laid down in the cao for Dutch Universities, Utrecht University has a number of its own arrangements. For example, there are agreements on professional development, leave arrangements and sports. We also give you the opportunity to expand your terms of employment yourself via the Employment Conditions Selection Model. This is how we like to encourage you to continue to grow.

Information

  • Position:  Technician
  • Location: Utrecht University, Utrecht, Netherlands
  • Duration: 1 year with a possible extension to 3-4 years or longer
  • Startdate: After consultation; as soon as possible
  • Background: Mass Spectrometry, (LC-MS/MS, proteomics, native mass spectrometry is considered a plus). Biochemical methodology, biochemistry
  • Apply with motivation letter, cv and 2 references
  • Deadline for application: open
  • For information or application: c.c.heuzer@nulluu.nl,  Corine Heuzer.