September 17th 2017
September 17th 2017
Five Post-doctoral and three PhD Vacancies
In the Heck group at Utrecht University a variety of exciting research projects seek motivated researchers to tackle them. The research emphasis is on the development of advanced mass spectrometry based methods for proteomics and structural biology.
The group houses an excellent infrastructure, including a dozen state-of-the-art mass spectrometers, advanced separation technologies, bioinformatics and laboratories for cell culture, biochemistry and molecular biology. The research group is vibrant with over 15 nationalities being present. Utrecht is a great place to be!
Short description of available Positions
Postdocs (minimum of 2 years)
Further optimization of native mass spectrometry, with the aim to generate even higher sensitivity and resolving power and secondly, optimize workflows for data-integration (e.g. middle-down, top-down and native) for both industrial enzymes and pharmaceutical proteins.
Quantitative proteomics, analysis of protein interactions and post-translational modifications using state-of-the art quantitative proteomics with an emphasis on the analysis of protein post-translational modifications. Applications will be mostly in virology and immunology.
Detailed characterization and de novo sequencing of endogenous antibodies, with the aim to pick up antibodies raised by our immune-system against invasions by pathogens.
Detailed characterization of proteins involved in the Complement pathway by hybrid mass spectrometry based methods including native mass spectrometry, proteomics, XL-MS and HD-MS.
Further optimization of top-down mass spectrometry, notably UV photodissociation and top-down sequencing of proteins and protein complexes. The project will be in collaboration with ThermoFisher Scientific and Maastricht University.
PhD Students (4 year program)
Development of high-resolution native mass spectrometry methods to characterize the complexity of pharmaceuticals and dairy proteins, including the characterization of isoforms and co-occurring PTMs.
Development of off-line and on-line couple, native separation methods with mass spectrometry, applied to biopharmaceuticals such as IgGs or other antibody-based therapeutics.
Detailed characterization and top-down and de novo sequencing of endogenous proteins and protein assemblies, with special emphasis on co-occurring protein isoforms.
Looking for a Postdoctoral Fellow:
In this project we aim to identify soluble factors present in melanoma patients’ plasma, that are responsible for systemic immune suppression, which hampers T cell activation upon checkpoint inhibitor treatment. In a collaborative effort with the NKI/AVL we will analyze systemic treatment naïve plasma samples by deep proteomic profiling from stage III melanoma patients that have progressed to stage IV. Changes in the profile of the identified proteins will be tested in an independent cohort of 100 melanoma patients treated with ipilimumab+nivolumab from whom we have collected baseline plasma samples.
For more information please contact Maarten Altelaar firstname.lastname@example.org