Simone Lemeer – Chemical- and Phosphoproteomics

Simone Lemeer – Chemical- and Phosphoproteomics


Simone Lemeer works on the elucidation of the mechanisms of action of small molecule inhibitors in cancer cells, as well as identification of the intrinsic resistance mechanisms. State of the art, high sensitive, chemical proteomics and phosphoproteomics technology are used to study the dynamic changes in response to small molecule inhibitor treatment.

Highlighted publications

See my citations on Google Scholar
  • Ruprecht B1, Koch H2, Medard G2, Mundt M2, Kuster B3, Lemeer S3. Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns. Mol Cell Proteomics. 2015 Jan;14(1):205-15. PMID: 25394399. [PubMed] [Read by QxMD]
  • Wilhelm M1, Schlegl J2, Hahne H3, Moghaddas Gholami A3, Lieberenz M4, Savitski MM5, Ziegler E4, Butzmann L4, Gessulat S4, Marx H6, Mathieson T5, Lemeer S6, Schnatbaum K7, Reimer U7, Wenschuh H7, Mollenhauer M8, Slotta-Huspenina J8, Boese JH4, Bantscheff M5, Gerstmair A4, Faerber F4, Kuster B9. Mass-spectrometry-based draft of the human proteome. Nature. 2014 May 29;509(7502):582-7. PMID: 24870543. [PubMed] [Read by QxMD]
  • Hahne H1, Pachl F, Ruprecht B, Maier SK, Klaeger S, Helm D, Médard G, Wilm M, Lemeer S, Kuster B. DMSO enhances electrospray response, boosting sensitivity of proteomic experiments. Nat Methods. 2013 Oct;10(10):989-91. PMID: 23975139. [PubMed] [Read by QxMD]
  • Marx H1, Lemeer S, Schliep JE, Matheron L, Mohammed S, Cox J, Mann M, Heck AJ, Kuster B. A large synthetic peptide and phosphopeptide reference library for mass spectrometry-based proteomics. Nat Biotechnol. 2013 Jun;31(6):557-64. PMID: 23685481. [PubMed] [Read by QxMD]
  • Lemeer S1, Zörgiebel C, Ruprecht B, Kohl K, Kuster B. Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity. J Proteome Res. 2013 Apr 5;12(4):1723-31. PMID: 23495751. [PubMed] [Read by QxMD]

 People working in the Lemeer group

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