AbLab: Your partner for Native Protein MS services

AbLab: Your partner for Native Protein MS services

AbLab provides state of the art Native MS services and is a service unit within the Heck lab. Due to this unique position AbLab has access to the latest insights, innovations, methodology and instrumentation for providing mass spectrometry services.

Native MS is emerging as a powerful technique for the characterization of antibodies, especially antibody mixtures, and in principle all therapeutic proteins. It provides the identity and accurate relative quantitative data of species in a mixture and complements, in many cases supersedes, conventional techniques such as cation exchange chromatography (CEX).

AbLab offers the following standardized services:

  • Qualitative analysis
    Antibodies and half-bodies in a mixture are identified base on their (theoretical and experimental) mass, according to a standard and documented procedure. It provides the identity of each species by mass determination and  a graphical presentation of the spectrum.
  • Semi-quantitative analysis
    Antibodies and half-bodies in a mixture are identified base on their (theoretical and experimental) mass and their relative abundance is determined according to a standard and documented procedure. It provides both the identity of each species in a mixture by mass determination, the relative abundance through comparison of relative ion signal intensities and  a graphical presentation of the spectrum. A semi-quantitative analysis is performed in triplicate.
  • Services available in the near future
    Analysis of drug antibody ratios and analysis of antibody derived proteins.

We are able to offer this service and produce an analytical report within 5-10 business days.

For more information and the services please click here

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