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Last year two first drafts of the human proteome were made available [1,2]. These drafts provide an overview of all proteins detected in different cells and tissues of our body. As proteins are the prime molecular entities responsible for all biological processes these drafts tell...

Top-down analysis of intact proteins by mass spectrometry provides an ideal platform for comprehensive proteoform characterization, in particular, for the identification and localization of post-translational modifications (PTM) co-occurring on a protein. One of the main bottlenecks in top-down proteomics is insufficient protein sequence coverage caused...

In a recent, open access, article in Molecular Systems Biology researchers from the Biomolecular Mass Spectrometry and Proteomics Group at Utrecht University and The Netherlands Cancer Institute in Amsterdam, report on an integrated analysis of proteomic and phospho‐proteomic data from BRAF inhibitor‐treated melanoma cells and...

Please take a moment to listen to the 'De Kennis Van Nu' radio interview (in Dutch) with Prof. Albert Heck, which took place on Tuesday, June 24th. The interview is amongst others about the first draft of the human protein catalogue. Just click here to tune...