ABSTRACT: Post-translational modifications (PTMs) play an impor- tant role in the regulation of protein function. Mass spectrometry based proteomics experiments nowadays identify tens of thousands of PTMs in a single experiment. A wealth of data has therefore become publically available. Evidently the biological function of each PTM is the...
Albert Heck, Tech Yew Low, Vincent Halim and Shabaz Mohammed of the Biomolecular Mass Spectrometry and Proteomics Group (Utrecht University) joined an international effort involving many renowned proteomics researchers and cell biologists to contribute to a contaminant repository for protein affinity purifications termed the CRAPome....
Reducing the parasite population with a virus The hitherto fairly unknown Triatoma virus, which kills insects that spread the tropical disease known as Chagas disease, could be used as a pesticide to control the insect plague and thus the spread of the disease. Researchers of the...
In a recent Nature paper researchers from the Hubrecht Institute in cooperation with researchers from the University Medical Center Utrecht (UMC Utrecht), University Utrecht (UU) and the Netherlands Proteomics Centre (NPC), describe a gene that limits the growth of intestinal adenomas. The research might be...
Genes & proteins involved in the regeneration of the small intestine uncovered In a collaboration involving several partners in the Utrecht Life Sciences Initiative (ULS) members of the Netherlands Proteomics Centre (Heck group) and the Hubrecht Institute (Clevers group, Alexander van Oudenaarden group, presently still at...
Reading chromatin modifications Michiel Vermeulen (Utrecht University) and his Dutch and German colleagues have applied quantitative mass spectrometry-based proteomics and ChIP-sequencing technology to discover and functionally characterise proteins that bind to methylated histone tails. The results have been published in Cell on 17 September 2010. In a...